A multidisciplinary group of subject matter experts analysed the reasons for suboptimal influenza immunization rates across the Middle East region using a methodology based upon the 6As taxonomy of determinants of vaccine uptake. They then identified targeted actions that countries could take to better protect their vulnerable populations against the influenza virus with vaccination. Organised by MENA-ISN and Irimi, the findings of the workshop were distilled into a Call-to-Action which is here in English, Arabic and French.